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Contraindicated (1)pentobarbital will lower the extent or impact of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals shouldn't choose estradiol valerate/dienogest as their contraceptive whilst applying robust CYP3A4 inducers as a consequence of possible lower in contraceptive efficacy.Indu